
    315 F. 2d 381; 137 USPQ 43
    In re Viktor Papesch
    (No. 6882)
    
      United States Court of Customs and Patent Appeals,
    March 20, 1963
    
      Selmuth A. Wegner, for appellant.
    
      Clarence W. Moore (Raymond E. Martin, of counsel) for the Commissioner of Patents.
    [Oral argument November 5, 1962, by Mr. Wegner and Mr. Martin]
    Before Worley, Chief Judge, and Rich, Martin, Smith, and Almond, Jr., Associate Judges.
   Rich, Judge,

delivered the opinion of the court:

This appeal is from the decision of the Patent Office Board of Appeals affirming the rejection of claims 1-3, the only claims presented in appellant’s application Ser. No. 836,870, filed August 31, 1959, for “2,4,6-TRIALKYLPYRAZOLO [4,3-d] -4,5,6,7-TETR A-HYDROPYRIMIDINE-5,7-DIONES.”

The specification, which is brief and occupies less than three pages •of the printed record, states:

The trialhyl compounds of this invention, have been found to possess unexpectedly potent anti-inflammatory activity in contrast to the related trimethyl •compound. The instant compounds are also diuretic agents.

Claim 1 reads:

A compound of the structural formula
wherein R is a lower alkyl radical containing more than one and less than five carbon atoms.

Claim 2 is specific to a compound within claim 1 wherein each R is an ethyl radical (which has, inter alia, 2 carbon atoms) and claim 3 is specific to the n-butyl compound wherein the alkyl radicals each •contain 4 carbon atoms. There are no other claims and the legal issue is such that it is unnecessary to distinguish between the claims.

Application PROsecution

The prosecution of this application was truly compact. On the first action the examiner rejected the claims on a single reference:

Robins et al., J. Am. Ohem. Soc., Vol. 78, pp. 2418-2422 (1956)

‘The action is so brief and to the point that we quote it in full:

Claims 1-3 are rejected as being unpatentable over Robins et al. Note Compound XVI. The ethyl and n-butyl side chains depicted in applicant’s claims 2 and 3 are obvious homologs of the methyl groups shown in identical positions in the reference compound and the method of preparation is substantially the same. (In re Henze, 636 O.G. 698). [Emphasis added.]

Compound XYI of the Robins et al. article is described by its structural formula which would be identical with that of appellant’s ■claim 1, supra, if all of the three R’s therein were methyl, — CH3, producing a trimethyl compound. There is textual reference to this and two other formulae, reading as follows:

Methylation of 5,7-dikydroxyprazolo[4,3-d]-pyrimidine with dimethyl sulfate in the presence of sodium hydroxide gave a compound CaHm02Ni isomeric with caffeine, presumably 1,4,6-trimethylpyrazolo[4,3-d] pyrimidine-5,7-dione( XV), although the possibility of the isomeric structure XVI for this compound has not been entirely eliminated. It is interesting to note that under the conditions of the experiment only one isomer was isolated. [Emphasis ours.]

By reason of this speculation on the part of Robins et al. as to whether they really produced XV or XVI, appellant points out that what the Patent Office relies on as prior art to show obviousness of the claimed compounds is the formula considered least likely by the authors. However, we give no weight to the speculative nature of the prior art compound because we do not believe that, in final analysis, appellant does so. His brief states:

The Robins et al. reference discloses, at best, that the lower homolog of the claimed compounds may possibly, exist, as a less likely alternative, and, if it does, how it is formed.

The case is really argued, however, on the assumption that a lower homolog of the claimed compounds is in the prior art and we shall proceed on that assumption. In other words, comparing the specific compound of claim 2 with the prior art, the compounds differ only in that where appellant has three ethyl groups the prior art has three methyl groups, a total difference of three — CH2 groups. Whether this meets the usual definitions of “homology” (according to two additional references to chemical texts made of record by the Patent Office) we do not stop to consider inasmuch as appellant has not argued the point. Indeed, we do not see why the Robins et al. compound XVI is not “the related trimethyl compound” referred to in the specification, quoted above.

The claims having been rejected on Robins et al., appellant responded by filing the affidavit of Dr. Francis J. Saunders (Ph. D. 1937), physiologist and a member, since 1938, of the Biology Division of G. D. Searle & Co., owner of the application at bar. Dr. 'Saunders has been in charge of Searle’s endocrinological and related physiological research. The affidavit reports comparative tests of the Robins et al. trimethyl compound and appellant’s triethyl compound which show that the latter is an active anti-inflammatory agent while the prior art compound is completely inactive in that respect. We need' not examine the tests in detail because the Patent Office has accepted. the factual conclusions of the affiant based on them.

We have before us, therefore, a single clean-cut issue of law.. The claims are rejected only on the ground that they are unpatentable over a.single reference which discloses what is conceded to be a lower homolog of the claimed compounds (whether or not all chemists would so consider it) and proof has been given showing that the compound of claim 2, “a representative member of” the group of compounds-claimed, possesses an advantageous pharmacological property shown not to be possessed by the prior art compound. In filing the affidavit, appellant stated in his response to the office action that the compounds of his claims 1 and 3 included more distantly related compounds than the triethyl compound tested and submitted that the showing of unpredictable and “completely dissimilar biological properties” established the patentability of the compounds he claimed.

The Examiner’s Views

The reply to this first response was a final rejection stating, in pertinent part:

The claimed compounds are obvious under 35 USO 103 in view of the reference. * * *. The affidavit is interesting hut irrelevant to the rejection since it is not directed to the subject matter “sought to be patented”, namely, the use in the arts of the compounds. The obvious compound is not made less obvious by its properties in an art use. * * *. It appears that if an invention is present, it resides in the use of the claimed compounds as anti-inflammatory agents and should be claimed as such. Therefore, it is held that the subject matter of the claim is obvious in view of the reference and unpatentable thereover.

The applicant appealed to the board, which took no notice of the-criticism that the invention should have been claimed as a “use.” Be-fore leaving this rejection, however, we make the observation that the ground of rejection seems to use somewhat confused, that it is unclear whether the affidavit was deemed truly irrelevant to the patentability of the claimed compounds, which alone were the “subject matter sought to be patented,” and unclear to what extent, if any, obviousness of the compounds was predicated on the contention that the applicant should claim his invention as a process, which is the only way a “use” can be claimed. 35 U.S.0.100 (b) and 101. The last sentence of the above quotation seems to involve a non sequitur.

The examiner who made the above rejection next filed a very long and very argumentative Examiner’s Answer, which reverts to the theme that appellant’s “contribution” was not in the novel compounds claimed per se, “but rather in the newly discovered properties which are advantageous for.a particular utility.” Said the examiner:

Such contribution may properly be protected by claims to the mode of employing the compounds for their unexpected novel use, but does not support claims covering compounds which are structurally obvious and which also exhibit a family of properties and characteristics common to, and not differing significantly from, those of the homologue known and available to the prior art. An unexpected difference in a single property should not be adequate to support a claim for a novel, but obvious, homologue, which claim will dominate all properties and uses of the homologue, including those differing only in the expected manner from the known product.

This passage being only an expression of what might be termed the background sentiments of the examiner, the actual rejection was legally predicated by him on section 103 and its essence is contained in the following quotation:

In view of the known general relationship of homology, the disclosure of an organic chemical structure immediately suggests and renders obvious to the organic chemist of ordinary skill its homologues, as organic compounds. The homologous compound being obvious it is not seen how it can become less obvious, as a compound, merely by discovering that in addition to the community of common physical and chemical properties expected of members of an homologues [sic] .series it also has other improved or valuable properties. Such discovery is not proper support for a patent for the compound per se. (In re Gauerke [24 CCPA 725, 86 F. 2d 330] 31 USPQ 330 and the decisions supra).

We will dispose now of the Gauerke case, which has no bearing on the issue here. It held only that it was not a patentable invention to use in an old resin composition containing drying oil, sunflower seed oil, which was known, and known also to be a drying oil, in place of other drying oil formerly used. The court said that incorporating sunflower seed oil in the resin was “a use which any one skilled in the art following the teachings of the prior art, might make of it.” We are here concerned with the patentability of a, new chemical compound having an inherent unknown, unobvious, pharmacologically advantageous property. Furthermore, nobody would be led by the prior art to use it for any purpose, so far as the record shows.

The Boakd Opinion

The Patent Office, for reasons undisclosed, convened a 5-man Board of Appeals to hear this case. It adopted a relatively long opinion (9 printed pages). We have tried as best we can to extract from it the essence of the board’s reasons for denying patentability, taking into consideration the supporting brief filed by the Patent Office Solicitor. We believe the reasoning to be along these lines:

1. The section 103 requirement of unobviousness is no different in chemical cases than with respect to other categories of patentable inventions. (We would accept that, in principle.)

2. From the viewpoint of the organic chemist the structures of the claimed compounds would be “obvious” from the Robins et al. reference disclosure of the related trimethyl compound as well as from the disclosure of methylation by conventional methods, which would suggest to a chemist “the use of ethylating or other alkylating agent of short chain length” as a possibility.

3. Appellant relies on a pharmacological property as the significant characteristic.

4. The statutory unobviousness required of a claimed chemical compound to make it patentable must be “considered from a chemical viewpoint,” i.e., from the viewpoint of chemists rather than pharmacologists, inasmuch as it is the chemists “who are involved with the synthesis of new compounds, and in their identification by physical characteristics and by reactions with other agents.”

5. In conclusion the board said :

We have considered the facts in this case from the viewpoint of the chemist and find that the compounds would, without a shadow of doubt, be obvious to the chemist from the disclosure in the Robins et al. publication. In these circumstances, the showing made in the affidavit cannot be considered persuasive of patentability.

As in the case of the examiner’s rejection, it is not clear from the above quotation whether or not the affidavit showing was ignored on the ground that the compounds would be obvious to a chemist, or because it did not relate to “chemical” properties. The solicitor argues that the above quoted paragraph shows that the board “weighed the effect of the affidavit” but he also says that the board considered that the homologous relationship and the “chemical facts” made the claimed compounds “so obvious * * * that the showing of the affidavit was ineffective ~by itself to demonstrate the unobviousness of the claimed compounds.” (Our emphasis.) Probably the best indication of how the board itself looked upon the affidavit is this paragraph from its opinion:

Such proof of advantages is not seen to occupy a different relationship than proof of commercial success or of the “filling of a long-felt want" often considered as sufficient to establish patentability in cases where some doubt of unobviousness eaAsts, but which have been consistently held as insufficient alone to override the holding of unpatentability in a clear case of obviousness. [Emphasis added.]

In view of that statement, and since the board found the compounds to be obvious “without a shadow of doubt,” we are bound to conclude that the board’s process of reasoning was first to look at the compounds as chemists to see if they were obvious and, having no doubt that they were, it found no reason to consider the “pharmacological” facts shown by the affidavit, the existence of which facts has never been questioned. This conforms with the solicitor’s oral argument which asked us to ignore the pharmacological properties on the ground that the claimed compounds were “so obvious.”

Opinion

The problem of “obviousness” under section 103 in determining the patentability of new and useful chemical compounds, or, as it is sometimes called, the problem of “chemical obviousness,” is not really a problem in chemistry or pharmacology or in any other related field of science such as biology, biochemistry, pharmacodynamics, ecology, or others yet to be conceived. It is a problem of patent law.

As everyone knows, section 103 is the statutory version of what was, prior to January 1, 1953, the effective date of the latest revision of the patent statutes, the judge-made requirement of “invention.” We are not unaware that we are, in this case, in the field of what has come to be called the “Hass-IIenze Doctrine,” though the briefs do not mention it by name. The Hass and Henze cases, which are mentioned, antedate section 103 and suggest, by way of dicta, that proof of the existence of unobvious or unexpected beneficial properties in a new compound, which would otherwise appear to be obvious (along with its properties), is indicative of the presence of “invention” and hence of patentability. What this comes down to, in final analysis, is a rather simple proposition: If that which appears, at first blush, to be obvious though new is shown by evidence not to be obvious, then the evidence prevails over surmise or unsupported contention and a rejection based on obviousness must fall. Many cases, both before and after the enactment of section 103, have been decided according to such reasoning and we shall now discuss a few of them.

Schering Corp. v. Gilbert, 153 F. 2d 428, 68 USPQ 84 (CCA 2d) was decided in 1946. The claim sustained was to a specific chemical compound. It was proved to possess unobvious and highly useful properties as an X-ray contrast agent in cholecystography. The court characterized the claimed invention, “a short claim for one definite chemical compound not found in nature and never previously synthesized,” as a “seemingly slight departure from the old.” Its approach to the question of patentability was stated thus:

* * * it is necessary to understand what the inventors did as well as what they sought to accomplish and gwe recognition to their end result as a novel and useful improvement, not in the art of organic chemistry hut in that of cholecystography. [Emphasis added.]

In Parker v. Marzall, 92 F. Supp. 736, 86 USPQ 446, a suit under R.S. 4915 decided in 1950, the District Court for the District of Columbia entered, among others, the following findings of fact and conclusion of law after having filed an “Informal Memorandum.” The findings of fact read:

7. The compound of plaintiffs’ claim 2 is the next adjacent homologue of the compound of said Bayer and Dahlen [prior art] patents. [An ethyl substituent on a ring where the references had methyl.]
8. The compound of plaintiffs’ claim 3 is the next adjacent homologue of the compound of plaintiffs’ claim 2 [ethyl in place of methyl as another ring substituent].
* ******
11. The evidence produced at the trial proves that the compounds claimed by the plaintiffs possess some unobvious and unexpected beneficial properties not possessed by the homologous compound disclosed in the prior art defense patents.

Conclusion of law:

2. In view of the evidence of unobvious, unexpected and beneficial properties of the compounds of plaintiffs’ claims 1, 2 and 3 not possessed by the homologous compound disclosed in the prior art, such claimed compounds constitute patentable invention. In re Hass et al., 141 F. 2d 122 [60 USPQ 544] (C.C.P.A. 1944).

The unobvious advantages here involved were found in yellow azo pigments made from the claimed compounds as intermediates.

In In re Schechter et al., 40 CCPA 1009, 205 F. 2d 185, 98 USPQ 144 (June 1953), this court reversed a rejection of claim 48 to a group of compounds (cyclopentenolones) which had been rejected as un-patentable over a prior art isomer. Biological function was taken into account in deciding in favor of patentability as shown by the following quotation:

We are convinced after a review of the record herein that, as appellants contend, there is a considerable degree of unpredictability in the insecticide field with homologs, isomers and anologs of known effective insectides having proven ineffective as insecticides. In view of this, and the other factors previously discussed, we conclude that all the compounds of the subgroup in Markush claim 48 are inventive and patentable over the prior art of record, albeit they include isomers and homologs of the compounds shown in LaForge et al. ¡Considering the history of the act at the time of the invention, the occasion for the invention, and its success, we think such a conclusion unavoidable.

Though the Patent Act of 1952 had just become effective and the court recognized its existence in referring to section 112, no mention was made of section 103 or the necessity of finding “unobviousness.” The court was still speaking in terms of the requirement of “invention,” its pre-revision equivalent in most respects. The court had previously stated, referring to In re Hass and another case, “We also implicitly indicated in the decisions 'here cited that homologs and isomers may be patentable if they are inventive over known prior art compounds,” citing Parker v. Marzall, supra, with evident approval.

In Ruskin v. Watson, 123 F. Supp. 33, 101 USPQ 275, the District Court for the District of 'Columbia decided in favor of patentability of a compound differing structurally from a compound already patented to the plaintiff only in the substitution of two ethyl groups in place of two hydrogen atoms. The compound was a therapeutic preparation used to control muscular spasm. The court quoted with approval the following dictum from the opinion of this court in the Henze case (footnote 3, supra):

*To those skilled in the chemical art, one homologue is not such an “advance” over an adjacent member of the series as requires invention, unless the beneficial properties realized in the new homologue lie clearly outside of the expeeta-tions which knowledge of his science would inform the trained chemist should be inherent in the product.

Finding that the claimed product had 'been shown by evidence to possess unobvious and unexpected beneficial properties not possessed by the previous patented compound, the court disapproved of the rejection and held the two compounds patentably distinct.

The same court in Stealing Drug Inc. v. Watson, 185 F Supp 173, 108 USPQ 37, gave judgment, in part, for plaintiff against the Commissioner of Patents in a suit under 35 U.'S.C. 145 to obtain a patent on claims to levo-arterenol and dextroarterenol. The prior art showed the racemic dl-arterenol and also the known next adjacent homologs of the claimed substances. The court found that “The evidence at the hearing abundantly supports the contention of the plaintiff that 1-arterenol in the form here claimed has phenomenal therapeutic properties with respect to the treatment of irreversible shock and coronary occlusion. * * * These qualities are utterly unattainable either by the dl-compound, from which the pure 1-arterenol is derived, or the admixture of 1-arterenol with its homologues.” The court said:

And there can hardly he any serious question that these beneficial characteristics were both unexpected and unobvious, which is the test to be applied in the matter of the patentability of a compound that is a homologue of another.
¡'fi * * * * & #
I have no hesitance in reaching the firm conclusion that the 1-arterenol * * * and the acid salt of 1-arterenol * * * and the 1-arterenol acid d-tartrate * * * are patentable. There is a difficulty with respect to claim 10, and that is that it also includes the claim to d-arterenol, and there has been no showing of any beneficial unexpected and unobvious properties of d-arterenol, and I, therefore, cannot conclude that d-arterenol is patentable.

It is interesting to observe here the applied principle working both ways. Where what we may call the apparent obviousness of the compound (including its properties) was overcome by evidence of unexpected advantageous properties the claim to it was held patentable; but where no such properties were shown to exist it remained an obvious compound with obvious properties.

In re Bergel et al., 48 CCPA 1102, 292 F. 2d 955, 130 USPQ 206, involved, inter alia, claims to chemotherapeutic agents rejected as un-patentable over the prior art. As to the position of the Patent Office on the closeness of the claimed compounds to the prior art, the opinion of the court says:

The examiner states that the compound of claims 1 and 2 is “a chlorine análog” of the Harper et al. compound, by which he apparently means that a part of the hydrogen of the Harper et al. compound is replaced by chlorine to form the claimed compounds. The examiner further noted that Everett et al. disclose compounds generally similar to those claimed by appellants and prepared by chlorination, and propose the use of such compounds in anti-tumor therapy.

In reversing the rejection the opinion says:

It is true that Harper et al. disclose compounds which, by the substitution of chlorine, a halogen, for part of the hydrogen, may be converted to the compounds recited in appealed claims 1 and 2, but, in our opinion, such conversion would not l>e obvious in the absence of any suggestion in the prior art as to why it should be made. [Emphasis added.]

And further:

The mere fact that it is possible to find two isolated disclosures which might be combined in such a way to produce a new compound does not necessarily render such production obvious unless the art contains something to suggest the desirability of the proposed combination.

In re Larsen, 49 CCPA 711, 292 F. 2d 531, 130 USPQ 209 (cert. denied, 133 USPQ 703), was an appeal taken only on process claims, claims to the product made by the process having been allowed. The appellant’s arguments drew into consideration by the court, however, the patentability of the products, as to which Chief Judge Worley made the following observations which are relevant here:

* * * the allowance of the claims to the compounds was based on the fact that they possessed unique, and presumably unexpected, properties. Since there was nothing to indicate that the compounds, when made, would have these properties, it was not obvious to malee the compounds. In such a case the allowance of claims to the compounds must depend on the proposition that it was unobvious to conceive the idea of producing them, within the meaning of Title 35 U.S.C., Section 103. [Emphasis added.]

The writer, in a concurring opinion, made the following observation:

There is a certain amount of logic in holding a product to be unobvious because of the discovery in it of unobvious properties, such as its ability to act as a nontoxic X-ray contrast agent, because the properties inhere in the product. [Emphasis added.]

In re Lambooy, 49 CCPA 985, 300 F. 2d 950, 133 USPQ 270, reversed the rejection of a single claim to an isoalloxazine compound. The decision was not handed down until after the briefs herein were filed. The only difference between the claimed compound and the prior art compound, riboflavin, was very much like the difference here — where riboflavin had two methyl groups, the claimed compound had two ethyl groups. It differed from riboflavin in a “pharmacological” property; where riboflavin acted in the animal body as a metabolite, the claimed compound, in spite of its “structural similarity,” acted as an antimetabolite. Judge Martin, speaking for a unanimous court, said:

A comparison of the structural formulas of these two compounds shows clearly that there is substantial structural similarity. But more appears from the facts of this case than structural similarity, facts which raise genuine questions as to the real significance of such bare structural similarity, whatever label may be attached to it.
* * * There is no evidence in the record which would lead one skilled in this art to expect that the differences in molecular structure between riboflavin and appellant’s compound would cause this difference in properties.

The next two quotations are so apt with respect to the arguments brought before us in the present case as to sound almost repetitious. We said in the Lambooy case:

The solicitor urges that “there is no specific evidence in the record of differences in chemical and physical properties of the prior art compound [riboflavin] and the claimed compound.” In view of the biochemical differences which we have just discussed, we can only assume the solicitor is urging that while differences in chemical properties might be persuasive of patentability of the claimed compound, differences in biochemical [original emphasis] properties are not to be considered. We see no reason to distinguish between chemical and biochemical properties and no reason or authority for this position has been presented to us. [Emphasis added.]
* * * * a 4 m
At the most, we think one skilled in this art would be taught by the reference patents that other groups than those present in the riboflavin structure can be attached to the parent isoalloxazine structure. We doubt that this fact is a noteworthy addition to the knowledge of an organic chemist of ordinary skill because he lenoivs this is true of all such parent chemical structures. Though this would be obvious to him, it does not follow that all new compounds so produced would be obvious in the sense of the patent law. [Emphasis added.]

In re Petering and Fall, 49 CCPA 993, 301 F. 2d 676, 133 USPQ, 275, also dealt with compounds stated to have antimetabolite activity as riboflavin antagonists. The rejection of claims 5, 11, and 12 on art was reversed. Judge Martin, again speaking for a unanimous court, said:

Although it is also true that some of the specific compounds of Karrer [the reference] * * * are structurally rather similar to the compounds defined in ■claims 5, 11 and 12, * * * there is a significant difference in properties between .appellants’ compounds and Karrer’s compounds. [Emphasis added.]
We do not agree with the board that the unexpected properties of the compounds defined in claims 5, 11 and 12 should not he considered in determining the patentability of these claims. The compounds are not described in Karrer within the meaning of 35 U.S.C. 102(b). In determining whether the claimed compounds are obvious within the meaning of 35 U.S.C. 103, we think their properties may and should be considered, and having considered the properties, we are convinced the compounds * * * are patentable over Karrer.

In that case, the board had taken essentially the same position it took in the present case, saying, “we are not convinced that the ascertainment of the property referred to could make such obvious compounds unobvious as compounds.”

From the foregoing cases it will be seen that this and other courts, both before and after the enactment of section 103, have determined the unobviousness and patentability of new chemical compounds by taking into consideration their biological or pharmacological properties. Nine of the ten cases above considered, directly and indirectly, involved such properties. Patentability has not been determined on the basis of the obviousness of structure alone. In fact, where patentability was found in the above cases it was found in spite of close similarity of chemical structure, often much closer similarity than we have here.

Returning now to the decision of the board in this case, we think that it rests on one fundamental error of law, namely, the failure to take into consideration the biological or pharmaceutical property of the compounds as anti-inflammatory agents on the ground that to chemists the structure of the compounds would be so obvious as to be beyond doubt, and that a showing of such properties is to be used only to resolve doubt.

From the standpoint of patent law, a compound and all of its properties are inseparable ,• they are one and the same thing. The graphic formulae, and the chemical nomenclature, the systems of classification and study such as the concepts of homology, isomerism, etc., are mere symbols by which compounds can be identified, classified, and compared. But a formula is not a compound and while it may serve in a claim to identify what is being patented, as the metes and bounds of a deed identify a plot of land, the thing that is patented is not the formula but the compound identified by it. And the patentability of the thing does not depend on the similarity of its •formula to that of another compound but of the similarity of the former compound to the latter. There is no basis in law for ignoring any property in making such a comparison. An assumed similarity based on a comparison of formulae must give way to evidence that the assumption is erroneous.

The argument has been made that patentability is here being asserted only on the basis of one property, the anti-inflammatory activity, and that the compounds claimed and the compound of the prior art presumably have many properties in common. Presumably they do, but presumption is all we have here. ’ The same is true of all of the compounds of the above cases which were held patentable over compounds of the prior art, many of which must have had more in common by way of properties than the compounds here because the relationships, structurally, were even closer than here.

As to the examiner’s view that in a case such as this the applicant should claim his invention as a process utilizing the newly discovered property, the board appears to have ignored it, properly we think. It is contrary to practically all of the above decisions wherein no fault was found with granting product claims. Such claims have well-recognized advantages to those in the business of making and selling compounds, in contrast to process-of-use claims, because competitors in the sale of compounds are not generally users.

The solicitor relies heavily on In re Finley and similar cases which we will now consider, arguing that there may be other factors to consider than a difference of a single advantageous property, which is true.

In re Finley, 36 CCPA 998, 174 F. 2d 130, 81 USPQ 383 (1949), was an appeal on a single claim reading: “As a composition of matter, 2 ethyl hexyl salicylate.” It was held unpatentable over several references which admittedly disclosed homologs and at least one isomer whose salts were all used as lubricant “additants,” the same use disclosed for salts of the claimed compound. An affidavit was submitted in the case showing that the calcium salt of the claimed compound had two to three times the thermal stability as lubricant “additant” as the calcium salt of the prior art isomer n-octyl salicylate. The board held the tests made on the calcium salts too remote, affirming the examiner who had said:

But to assert that the property of the salt or of the oil is the property of the ester is clearly a confusion of the issue.

The passage in the Finley opinion relied on by the Patent Office is:

Obviously appellant construes our holding in those [Hass et al.] cases to mean that if a new and useful product does show uno'bvious or unexpected beneficial properties it follows that such a product is patentable. We did not affirmatively, or even by implication, so state in our decisions there. Our statement meant merely that unless a product does show the defined characteristics it is not patentable. Even if they be shown, the consideration of other factors may be required. As we said in our decision in the second Hass et al. case, supra, “Whether novel chemical compounds are patentable over prior art isomers and homologues is a question to be determined in each ease.”

The principle of the above passage was also reiterated the next year in In re Henze, 37 CCPA 1009, 181 F. 2d 196, 85 USPQ 261, in the following words:

Patentability is not resolved conclusively even where unexpected or unobvious beneficial properties are established to exist in novel members of a homologous series over prior art members, as the circumstances of the case may require a consideration of other factors, [citing Finley] A mere difference in degree is not the marked superiority which ordinarily will remove the unpatentability of adjacent homologues of old substances. In re Loring Coes, Jr., supra [36 CCPA 1067, 173 P. 2d 1012, 81 USPQ 369]. [Emphasis added.]

In the Loring Goes case the invention was an abrasive grinding wheel. It was specifically found that “the improvement, if any, is one of degree viewed only from a single aspect.” The new grinding wheel was shown to wear longer, but the old wheel was shown to be more efficient in the amount of metal removed per unit of time. The invention related to the synthetic resin binder in the wheel which differed only slightly in composition from prior resin binders, the difference residing only in the hardening agent used. The hardener selected differed from a known prior art hardening agent only by the omission of one —CH2 group out of six, found in triglycol dichloride, and was held to be an unpatentable selection.

The other factor of importance which was present in the Finley, Heme, and Goes cases and others of their type is that the prior art disclosure was not merely of a structurally similar compound but also, at least to a degree, of the same desired property relied on for patent-ability in the new compound. Such an “other factor” must of course be considered because it bears on the obviousness of the compound, which is, realistically and legally, a composite of both structure and properties.

As should be apparent from the foregoing, we regard the board’s opinion and decision as contary to well established law. We see no reason to change that law. The decision is therefore reversed.

Worley, C. J., concurs in result only. 
      
       In this connection, see “The Forgotten Chemistry of the Hass-Henze Doctrine,” by Bruce M. Collins, Journal of the Patent Office Society, April, 1962, Vol. XLIV, No. 4, page 2S4. Note also that lm the first office action the examiner did not say that appellant’s compounds are homologs of the Robins et al. compound XVI. He said, “The ethyl and n-butyl side chains * * * In applicant’s claims • * * are obvious homologs of the methyl groups * * • In the reference * * [Emphasis ours.]
     
      
      
         It Is noted that certain supposed facts are here being assumed. It Is true that the applicant submitted proof as to only one unexpected, unobvlous, beneficial property. The examiner’s statements about the existence of a family of other properties common to the claimed compounds and the compound of the prior art finds support in the record, however, only on the basis of assumptions In turn based on assumed “homology.” In his answer, the examiner cited a new reference, Wertheim “Textbook of Organic Chemistry” (2d Ed.), page 37 (1945). From it he quoted the following statement about members of “any one homologous series
      These compounds have similar chemical traits, because their structures are closely related; therefore we can learn the chemistry of the entire group with no more effort than would otherwise be required to study a single compound.
      ■He had previously cited in his final rejection another new reference, Fieser and Fieser, “Organic Chemistry,” 3d Ed., pages 30-31 (1956), which pages deal, so far as pertinent, only with the progressive relationships in the CnH2i>+» homologous series, with bare mention of similar relationships existing in the halogens: chlorine, bromine, and iodine.
      Wertheim, at the point from which the above quotation was taken, was discussing the same “methane series of hydrocarbons” as Fieser and Fieser. The examiner stopped his quotation just before the sentence reading, “Of course we may anticipate certain ‘exceptions’ to this general rule, but such exceptions will make very little trouble.” We are not here dealing with the methane series or with the type of “homology” which it illustrates.
      We have had sufficient contact with “homology” on this court to agree with the examiner that such similarity in structure as exists here probably indicates similarity in some undisclosed properties; but we are past giving too much legal significance to the bare term “homolog,” even where there is an admission of homology, as there appears to be here. The term is often used loosely. So far as we know, the assumed- similarities referred to by the examiner are of little or no practical or commercial significance. Certainly he has pointed to none. On the other hand, the proven dissimilarity is a matter of pharmacological significance, on which the examiner would be quite willing to grant a patent if the invention were claimed as a process. As to the other properties, nothing in the record gives us any information, not even the Robins et al. reference.
     
      
       This “doctrine” was evolved by the bar from this court’s opinions in the three cases called In re Hass et al., 31 CCPA 895, 903, 908, 141 F. 2d 122, 127, 130, 60 USPQ 544, 548, 552, and in In re Henze, 37 CCPA 1009, 181 F. 2d 196, 85 USPQ 261. See “The Hass-Henze Doctrine,” by Alvin Guttag, Dec. 1961 JPOS, Vol. XD1II, No. 12, p. 808. This article commences with a discussion of what is meant by “homolog” and sets forth a definition which would exclude the compounds involved in the present case. In spite of all the talking and writing on the subject, we are not quite sure what the doctrine is but, whatever it is, insofar as the Bass and Benze cases are concerned, it appears to be based on dicta, since all of those eases affirmed the Patent Office rejections. For some observations on the limitations of the Benze case and the significance of homology, see In re Victor Mills, 47 CCPA 1185, 281 F. 2d 218, 126 USPQ 513.
     
      
       We are sure that our predecessors In here referring to “those skilled in the chemical art” and to “chemists” were not, In the Heme case, using these terms in any such narrow sense as the board is doing in the instant case, so as to exclude biologists, pharmacologists, medical clinicians, or any other competent trained personnel who carry on investigative work in the general field of drugs, for the subject matter being discussed in that case, both prior art and claimed, was certain compounds having, or alleged to have, hypnotic, soporific or narcotic effect. The case went off on failure to prove that the claimed compound and the next adjacent homolog (in the strict sense of differing by one —CH2 group) did not have the same advantageous high anticonvulsant activity with low toxicity which the examiner contended would be expected.
     
      
      
         None of the opinions in this case show, specifically, what the claimed compounds are useful for. The specification of the appealed application states the utility as follows :
      My new compounds are useful as X-ray contrast agents and are particularly valuable for visualizing the bronchial tree (bronchography), and for hepatolienography (visualization of the liver and spleen).
      At least in the latter use the compounds would have to be ingested and to reach the liver and spleen by biological body processes. This is in the field of what the board deemed to be pharmacology rather than chemistry.
     